The N-end rule: functions, mysteries, uses.
نویسنده
چکیده
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. I discuss the mechanisms and functions of this pathway, and consider its applications.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 93 22 شماره
صفحات -
تاریخ انتشار 1996